The Potential Role of Polyelectrolyte Complex Nanoparticles Based on Cashew Gum, Tripolyphosphate and Chitosan for the Loading of Insulin

Polyelectrolytic complexation has stood out due to its application in the development of drug delivery systems using biopolymers as raw materials. The formation complexes between cashew gum and chitosan can be intermediated by cross-links, mediated action sodium tripolyphosphate crosslinking agent. These polymers have been used nanotechnological formulations protect peptide drugs, such insulin, allowing their oral administration. In this work, we describe polyelectrolytic from for administration insulin. obtained showed a mean particle size 234 nm polydispersity index 0.2. were size, PDI 0.2, zeta potential ?4.5 mV 22% trapping. demonstrated considerable promising characteristics use insulin systems.